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Search: WFRF:(Nilsson Peter) > Lyssenko Valeriya > Morken Mario A. > Meta-analysis of ge...

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Zeggini, Eleftheria (author)
Scott, Laura J. (author)
Saxena, Richa (author)
show more...
Voight, Benjamin F. (author)
Marchini, Jonathan L. (author)
Hu, Tianle (author)
de Bakker, Paul I. W. (author)
Abecasis, Goncalo R. (author)
Almgren, Peter (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Andersen, Gitte (author)
Ardlie, Kristin (author)
Bostroem, Kristina Bengtsson (author)
Bergman, Richard N. (author)
Bonnycastle, Lori L. (author)
Borch-Johnsen, Knut (author)
Burtt, Noel P. (author)
Chen, Hong (author)
Chines, Peter S. (author)
Daly, Mark J. (author)
Deodhar, Parimal (author)
Ding, Chia-Jen (author)
Doney, Alex S. F. (author)
Duren, William L. (author)
Elliott, Katherine S. (author)
Erdos, Michael R. (author)
Frayling, Timothy M. (author)
Freathy, Rachel M. (author)
Gianniny, Lauren (author)
Grallert, Harald (author)
Grarup, Niels (author)
Groves, Christopher J. (author)
Guiducci, Candace (author)
Hansen, Torben (author)
Herder, Christian (author)
Hitman, Graham A. (author)
Hughes, Thomas E. (author)
Isomaa, Bo (author)
Jackson, Anne U. (author)
Jorgensen, Torben (author)
Kong, Augustine (author)
Kubalanza, Kari (author)
Kuruvilla, Finny G. (author)
Kuusisto, Johanna (author)
Langenberg, Claudia (author)
Lango, Hana (author)
Lauritzen, Torsten (author)
Li, Yun (author)
Lindgren, Cecilia M. (author)
Lyssenko, Valeriya (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Marvelle, Amanda F. (author)
Meisinger, Christa (author)
Midthjell, Kristian (author)
Mohlke, Karen L. (author)
Morken, Mario A. (author)
Morris, Andrew D. (author)
Narisu, Narisu (author)
Nilsson, Peter (author)
Owen, Katharine R. (author)
Palmer, Colin N. A. (author)
Payne, Felicity (author)
Perry, John R. B. (author)
Pettersen, Elin (author)
Platou, Carl (author)
Prokopenko, Inga (author)
Qi, Lu (author)
Qin, Li (author)
Rayner, Nigel W. (author)
Rees, Matthew (author)
Roix, Jeffrey J. (author)
Sandbaek, Anelli (author)
Shields, Beverley (author)
Sjögren, Marketa (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Steinthorsdottir, Valgerdur (author)
Stringham, Heather M. (author)
Swift, Amy J. (author)
Thorleifsson, Gudmar (author)
Thorsteinsdottir, Unnur (author)
Timpson, Nicholas J. (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Walker, Mark (author)
Watanabe, Richard M. (author)
Weedon, Michael N. (author)
Willer, Cristen J. (author)
Illig, Thomas (author)
Hveem, Kristian (author)
Hu, Frank B. (author)
Laakso, Markku (author)
Stefansson, Kari (author)
Pedersen, Oluf (author)
Wareham, Nicholas J. (author)
Barroso, Ines (author)
Hattersley, Andrew T. (author)
Collins, Francis S. (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
McCarthy, Mark I. (author)
Boehnke, Michael (author)
Altshuler, David (author)
show less...
 (creator_code:org_t)
2008-03-30
2008
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:5, s. 638-645
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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art (subject category)
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By the author/editor
Zeggini, Elefthe ...
Scott, Laura J.
Saxena, Richa
Voight, Benjamin ...
Marchini, Jonath ...
Hu, Tianle
show more...
de Bakker, Paul ...
Abecasis, Goncal ...
Almgren, Peter
Andersen, Gitte
Ardlie, Kristin
Bostroem, Kristi ...
Bergman, Richard ...
Bonnycastle, Lor ...
Borch-Johnsen, K ...
Burtt, Noel P.
Chen, Hong
Chines, Peter S.
Daly, Mark J.
Deodhar, Parimal
Ding, Chia-Jen
Doney, Alex S. F ...
Duren, William L ...
Elliott, Katheri ...
Erdos, Michael R ...
Frayling, Timoth ...
Freathy, Rachel ...
Gianniny, Lauren
Grallert, Harald
Grarup, Niels
Groves, Christop ...
Guiducci, Candac ...
Hansen, Torben
Herder, Christia ...
Hitman, Graham A ...
Hughes, Thomas E ...
Isomaa, Bo
Jackson, Anne U.
Jorgensen, Torbe ...
Kong, Augustine
Kubalanza, Kari
Kuruvilla, Finny ...
Kuusisto, Johann ...
Langenberg, Clau ...
Lango, Hana
Lauritzen, Torst ...
Li, Yun
Lindgren, Cecili ...
Lyssenko, Valeri ...
Marvelle, Amanda ...
Meisinger, Chris ...
Midthjell, Krist ...
Mohlke, Karen L.
Morken, Mario A.
Morris, Andrew D ...
Narisu, Narisu
Nilsson, Peter
Owen, Katharine ...
Palmer, Colin N. ...
Payne, Felicity
Perry, John R. B ...
Pettersen, Elin
Platou, Carl
Prokopenko, Inga
Qi, Lu
Qin, Li
Rayner, Nigel W.
Rees, Matthew
Roix, Jeffrey J.
Sandbaek, Anelli
Shields, Beverle ...
Sjögren, Marketa
Steinthorsdottir ...
Stringham, Heath ...
Swift, Amy J.
Thorleifsson, Gu ...
Thorsteinsdottir ...
Timpson, Nichola ...
Tuomi, Tiinamaij ...
Tuomilehto, Jaak ...
Walker, Mark
Watanabe, Richar ...
Weedon, Michael ...
Willer, Cristen ...
Illig, Thomas
Hveem, Kristian
Hu, Frank B.
Laakso, Markku
Stefansson, Kari
Pedersen, Oluf
Wareham, Nichola ...
Barroso, Ines
Hattersley, Andr ...
Collins, Francis ...
Groop, Leif
McCarthy, Mark I ...
Boehnke, Michael
Altshuler, David
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
Articles in the publication
Nature Genetics
By the university
Lund University

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